Protein Ligand Docking Study of Cetirizine on HERG Receptor

Authors

  • Shukla KV Shri Ram Institute of Pharmacy, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Jabalpur, India
  • Sharma V Shri Ram Institute of Pharmacy, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Jabalpur, India

Keywords:

Liagand, Potassium Membrane, Gene, HERG

Abstract

HERG is the protein which is found in the potassium ion channel which is mainly used to check the cardiac action of heart in which we can see the heart rhythm and its abnormality by the Q.T syndrome through electro gram where Q.T interval was extended or prolonged for that the various reports are coming for sudden death due to cardiac arrest.

References

[1] Zeltser D, Justo D, Halkin A, Prokhorov V, Heller K, Viskin S. Torsade de pointes Due to Noncardiac Drugs: Most Patients Have Easily Identifiable Risk Factors. Medicine (Baltimore). 2003; 82:282–290.

[2] Hancox JC, McPate MJ, El Harchi A, Zhang YH. The HERG Potassium Channel and HERG Screening For Drug-Induced Torsades de Pointes. Pharmacol Ther. 2008; 119:118–132

[3] Lees-Miller, J. P., Duan, Y., Teng, G. Q. & Duff, H. J. Molecular Determinant of High-Affinity Dofetilide Binding to HERG1 Expressed in Xenopus Oocytes: Involvement of S6 Sites. Mol. Pharmacol. 57, 367–374 (2000).

[4] Curran MP, scott LJ, Perry CM. Cetirizine: a Review of Its Use in Allergic Disorders. Drugs 2004; 64: 523–61.

[5] Mitcheson JS, Chen J, Sanguinetti MC. Trapping of a Methane Sulfonanilide by Closure of the HERG Potassium Channel Activation Gate. J Gen Physiol. 2000; 115:229–240

[6] Sheiner L, Beal S. Nonmem, Version 5.1. Nonmem Project Group. San Francisco: University of California, 1998.

[7] Carmeliet,e.(1993). Use-Dependent Block and Use-Dependent Unblock of the Delayed Rectifier k+ Current by Almokalant in Rabbit Ventricular Myocytes. circ. Res.,73,857–868.

[8] Keating,m.t.&Sanguinetti,m.c.(2001).Molecular and Cellular Mechanisms of Cardiac Arrhythmias.Cell,104,569–580.

[9] Bucchi A, Baruscotti M, Nardini M, Barbuti A, Micheloni S, Bolognesi M, DiFrancesco D. Identification of the Molecular Site of Ivabradine Binding to HCN4 Channels. PLoS One. 2013; 8:e53132

Downloads

Published

2025-11-25

How to Cite

[1]
K. V. Shukla and V. Sharma, “Protein Ligand Docking Study of Cetirizine on HERG Receptor”, Int. J. Comp. Sci. Eng., vol. 7, no. 10, pp. 1–3, Nov. 2025.